Cytotoxic Drug Safety Cabinet
Applications Cytotoxic drug safety cabinets are defined as the primary barrier against exposure to aerosols that are produced in the preparation, manipulation and dispensing of cytotoxic drugs. Many of these drugs are known to be mutagens, and are suspected of being carcinogens and teratogens. These effects are insidious and may not manifest themselves for some years. The requirements for protection involve the following: Protection of cabinet users and other staff from exposure to aerosols or vapours which may be generated in the preparation, manipulation and dispensing of cytotoxic drugs. Protection of drug products, so that they may be prepared in an environment which is essentially free from particulate and biological contamination. Protection of cabinet maintenance personnel from the residue of drug particles which can contaminate filters, fans and other mechanical components. Australian Standards The need for a new cabinet design led to the publication in 1982 of AS2567, the world's first standard for cytotoxic drug safety cabinets. AS2639, first published in 1983, deals with cabinet use and installation, including the location of the cabinet in a special cleanroom. Revised versions of these documents were published in 1994. CG2000 Cytogard cabinets are designed and manufactured to comply with AS2567, and each cabinet is factory-certified by a NATA-registered laboratory to meet the specified performance requirements. These cabinets may also be used where the handling of other drugs and chemicals requires both containment and aseptic manipulation. Please refer to our Standards page. Description CG2000 cabinets are part-recirculating laminar air flow enclosures with high efficiency particulate air (HEPA) filtration of exhaust air and an air barrier at the work opening. HEPA-filtered vertical laminar air flow which is recirculated in the work zone creates an ultra-clean work environment for product protection. An air barrier between the operator and the work zone is maintained by a flow of room air into a full-width grille in the work opening. The barrier air mixes with the recirculated laminar flow air in a sump underneath the work surface, and is exhausted from the cabinet via a HEPA filter which is located directly under the work tray. All positive pressure zones and filter seals are surrounded by negative pressure zones, so as to contain potentially hazardous aerosols. Cabinets are produced with a work zone width of 90cm, 120cm or 180cm and are free standing units that incorporate a floor stand. Standard cabinets have exhaust discharge on the right hand side with optional left hand side or top exhaust available. Top exhaust is typically specified where cabinet exhaust air is to be entrained into the room exhaust. These cabinets provide advanced system-monitoring technology and a number of unique design features intended to enhance safety and ease of use. Construction Cabinet. Work zone.
A pneumatic mechanism opens and closes the viewing window without the need for external fasteners or catches. The window is self-supporting in the fully-open position to facilitate cleaning and access for large items. Opening the window with the cabinet running automatically engages a boost mode for enhanced containment by activating maximum exhaust airflow and the alarm systems. Fans.
Audible and visible alarms with rechargeable battery back-up signify any reduction in barrier containment or laminar airflow. HEPA filters.
A prefilter extends the life of the exhaust HEPA filter, and protects it from mechanical damage during cleaning of the work zone. Physical Data
*Made to special order. To facilitate transport and installation, cabinets may be separated into two modules. Call for details. Electrical.
An integral fluorescent lamp housing reduces heat build-up near the operator. Glare-free lamps provide a minimum lighting intensity of 800 lux at the work floor. Quality Assurance and Control Clyde-Apac laminar flow and HEPA filter products are manufactured in Australia under an accredited Total Quality Management System. Please refer to our Standards page. Standard features Low voltage touch controls Diagnostics system with digital display monitoring critical functions Alarms and boost mode automatically engaged when viewing window is open Boost mode selectable at control panel Selectable post-use over-run timer Pneumatically-operated viewing window Hourmeter to record operating time Fully-sealed work opening cover for testing procedures Comprehensive operation and maintenance manual Options Activated-carbon exhaust filter IV hanging rail and hooks Magnehelic gauge to monitor fan systems Splashproof power outlet Germicidal UV lamp Gas tap with solenoid valve Vacuum tap with 0.2m filter Exhaust discharge on left hand side or top
CG2000 Series cabinets are factory-tested and certified by a NATA registered laboratory. Additional testing and certification should be carried out on site prior to use, and subsequently: After any electrical or mechanical maintenance After filter replacement After re-location At least annually In special circumstances, such as significant change in the work programme, or where unsafe cabinet operation is suspected AES Environmental is a NATA-registered laboratory and provides comprehensive on-site maintenance, testing and certification services for safety cabinets, laminar flow work stations, cleanrooms and HEPA filter installations. This service is available from fully-equipped, NATA-registered laboratories in major Australian centres. Due to ongoing research & development, Clyde-Apac reserves the right to modify the product & specifications without notice. |
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